Molecular insights into the increased transmissibility and immunity evasion of the SARS-CoV-2 Alpha variant Yang TJ, Yu PY, Chang YC, Liang KH, Tso HC, Ho MR, Chen WY, Lin HT, Wu HC, Hsu STD* The Alpha variant of SARS-CoV-2, also known as the B.1.1.7 strain, was first identified in the UK in late 2020. It soon spread across the world before being overtaken by the Delta variant that emerged in India ... Read more

Copper Centers in the Cryo-EM Structure of Particulate Methane Monooxygenase Reveal the Catalytic Machinery of Methane Oxidation Chang WH*, Lin HH, Tsai IK, Huang SH, Chung SC, Tu IP, Yu SSF*, Chan SI* The particulate methane monooxygenase (pMMO) is the first enzyme in the C1 metabolic pathway in methanotrophic bacteria. As this enzyme converts methane into methanol efficiently near room temperature ... Read more

Effect of SARS-CoV-2 B.1.1.7 mutations on spike protein structure and function.

Yang TJ, Yu PY, Chang YC, Liang KH, Tso HC, Ho MR, Chen WY, Lin HT, Wu HC, Hsu STD* Nature Structural & Molecular Biology (2021)

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Copper Centers in the Cryo-EM Structure of Particulate Methane Monooxygenase Reveal the Catalytic Machinery of Methane Oxidation.

Chang WH*, Lin HH, Tsai IK, Huang SH, Chung SC, Tu IP, Yu SSF*, Chan SI* J. Am. Chem. Soc. (2021)

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Preparation of High-Temperature Sample Grids for Cryo-EM.

Chang YC, Chen CY, Tsai MD* Jove - Journal of Visualized Experiments (2021)

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