| Research Highlights |
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Direct Visualization of a 26 kDa Protein by Cryo-Electron Microscopy Aided by a Small Scaffold Protein |
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Chiu YH, Ko KT, Yang TJ, Wu KP, Ho MR, Draczkowski P*, Hsu STD*
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Perfection in the imperfection – molecular mechanism for genetic diversity |
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Luo SC, Yeh HY, Lan WH, Wu YM, Yang CH, Chang HY, Su GC, Lee CY, Wu WJ, Li HW, Ho MC*, Chi P*, Tsai MD*
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Through the looking glass of cryoEM, unveiling the unique molecular structure and camouflaging sugar coating of feline coronavirus surface spike protein |
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Yang TJ, Chang YC, Ko TP, Draczkowski P, Chien YC, Chang YC, Wu KP, Khoo KH, Chang HW*, Hsu STD*
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Sharp Tools Make Good Work: The Early Success of ASCEM |
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Chen CY, Chang YC, Lin BL, Lin KF, Huang CH, Hsieh DL, Ko TP, Tsai MD
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New Research Highlight on the Lon Protease |
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Chien-Chu Lin, Shih-Chieh Su, Ming-Yuan Su, Pi-Hui Liang, Chia-Cheng Feng, Shih-Hsiung Wu, Chung-I Chang |
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Shih-Chieh Su, Chien-Chu Lin, Hui-Chung Tai, Mu-Yueh Chang, Meng-Ru Ho, C. Satheesan Babu, Jiahn-Haur Liao, Shih-Hsiung Wu, Yuan-Chih Chang, Carmay Lim, Chung-I Chang |
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| Latest Publication |
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Direct Visualization of a 26 kDa Protein by Cryo-Electron Microscopy Aided by a Small Scaffold Protein. |
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Chiu YH, Ko KT, Yang TJ, Wu KP, Ho MR, Draczkowski P*, Hsu STD*
Biochemistry (2021)
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Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures. |
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Luo SC, Yeh HY, Lan WH, Wu YM, Yang CH, Chang HY, Su GC, Lee CY, Wu WJ, Li HW, Ho MC*, Chi P*, Tsai MD*
Nat Commun (2021)
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A carbohydrate-binding protein from the edible Lablab beans effectively blocks the infections of influenza viruses and SARS-CoV-2. |
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Liu YM, Mahmud Md. SA, Chen XR, Chen TH, Liao KS, Lo JM, Wu YM, Ho MC, Wu CY, Wong CH, Jan JT, Ma C
Cell Reports (2020)
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Cryo-EM analysis of a feline coronavirus spike protein reveals a unique structure and camouflaging glycans. |
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Yang TJ, Chang YC, Ko TP, Draczkowski P, Chien YC, Chang YC, Wu KP, Khoo KH, Chang HW, Hsu STD
PNAS (2020)
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Temperature-Resolved Cryo-EM Uncovers Structural Bases of Temperature-Dependent Enzyme Functions. |
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Chen CY, Chang YC, Lin BL, Huang CH, Tsai MD
J Am Chem Soc. (2019)
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Use of Cryo-EM to Uncover Structural Bases of pH Effect and Cofactor Bi-specificity of Ketol-acid Reductoisomerase. |
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Chen CY, Chang YC, Lin BL, Lin KF, Huang CH, Hsieh DL, Ko TP, Tsai MD
J Am Chem Soc. (2019)
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3D mitochondrial ultrastructure of Drosophila indirect flight muscle revealed by serial-section electron tomography. |
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Jiang YF, Lin HL, Fu CY
J Vis Exp. (2017)
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Electron tomographic analysis reveals ultrastructural features of mitochondrial cristae architecture which reflect energetic state and aging. |
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Jiang YF, Lin SS, Chen JM, Tsai HZ, Hsieh TS, Fu CY
Sci Rep. (2017)
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Structural Basis for the Magnesium-Dependent Activation and Hexamerization of the Lon AAA+ Protease. |
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Su SC, Lin CC, Tai HC, Chang MY, Ho MR, Babu CS, Liao JH, Wu SH, Chang YC, Lim C, Chang CI
Structure (2016)
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EM structure of a helicase-loader complex depicting a 6:2 binding sub-stoichiometry from Geobacillus kaustophilus HTA426. |
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Lin YC, Naveen V, Hsiao CD.
Biochem Biophys Res Commun (2016)
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Structure of yeast Ape1 and its role in autophagic vesicle formation. |
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Su MY, Peng WH, Ho MR, Su SC, Chang YC, Chen GC, Chang CI
Autophagy (2015)
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