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Research Highlights
 
Through the looking glass of cryoEM, unveiling the unique molecular structure and camouflaging sugar coating of feline coronavirus surface spike protein
  Yang TJ, Chang YC, Ko TP, Draczkowski P, Chien YC, Chang YC, Wu KP, Khoo KH, Chang HW*, Hsu STD*
Sharp Tools Make Good Work: The Early Success of ASCEM
  Chen CY, Chang YC, Lin BL, Lin KF, Huang CH, Hsieh DL, Ko TP, Tsai MD
New Research Highlight on the Lon Protease
 
1. Chien-Chu Lin, Shih-Chieh Su, Ming-Yuan Su, Pi-Hui Liang, Chia-Cheng Feng, Shih-Hsiung Wu, Chung-I Chang
2.
 
Shih-Chieh Su, Chien-Chu Lin, Hui-Chung Tai, Mu-Yueh Chang, Meng-Ru Ho, C. Satheesan Babu, Jiahn-Haur Liao, Shih-Hsiung Wu, Yuan-Chih Chang, Carmay Lim, Chung-I Chang
 
Latest Publication
 
A carbohydrate-binding protein from the edible Lablab beans effectively blocks the infections of influenza viruses and SARS-CoV-2.
  Liu YM, Mahmud Md. SA, Chen XR, Chen TH, Liao KS, Lo JM, Wu YM, Ho MC, Wu CY, Wong CH, Jan JT, Ma C
Cell Reports (2020)
Cryo-EM analysis of a feline coronavirus spike protein reveals a unique structure and camouflaging glycans.
  Yang TJ, Chang YC, Ko TP, Draczkowski P, Chien YC, Chang YC, Wu KP, Khoo KH, Chang HW, Hsu STD
PNAS (2020)
Temperature-Resolved Cryo-EM Uncovers Structural Bases of Temperature-Dependent Enzyme Functions.
  Chen CY, Chang YC, Lin BL, Huang CH, Tsai MD
J Am Chem Soc. (2019)
Use of Cryo-EM to Uncover Structural Bases of pH Effect and Cofactor Bi-specificity of Ketol-acid Reductoisomerase.
  Chen CY, Chang YC, Lin BL, Lin KF, Huang CH, Hsieh DL, Ko TP, Tsai MD
J Am Chem Soc. (2019)
3D mitochondrial ultrastructure of Drosophila indirect flight muscle revealed by serial-section electron tomography.
  Jiang YF, Lin HL, Fu CY
J Vis Exp. (2017)
Electron tomographic analysis reveals ultrastructural features of mitochondrial cristae architecture which reflect energetic state and aging.
  Jiang YF, Lin SS, Chen JM, Tsai HZ, Hsieh TS, Fu CY
Sci Rep. (2017)
Structural Basis for the Magnesium-Dependent Activation and Hexamerization of the Lon AAA+ Protease.
  Su SC, Lin CC, Tai HC, Chang MY, Ho MR, Babu CS, Liao JH, Wu SH, Chang YC, Lim C, Chang CI
Structure (2016)
EM structure of a helicase-loader complex depicting a 6:2 binding sub-stoichiometry from Geobacillus kaustophilus HTA426.
  Lin YC, Naveen V, Hsiao CD.
Biochem Biophys Res Commun (2016)
Structure of yeast Ape1 and its role in autophagic vesicle formation.
  Su MY, Peng WH, Ho MR, Su SC, Chang YC, Chen GC, Chang CI
Autophagy (2015)
 

Contact: Ms. Hsin-Hua Lin, Academia Sinica CryoEM Center   Email:cryoem@gate.sinica.edu.tw

No. 128, Sect. 2, Academia Rd., Nankang, Taipei 115, Taiwan (R.O.C.)      TEL:(02) 27855696 #3020

(Lab) B2-I04 (Interdisciplinary Sci. & Tech. Building), No. 28, Ln. 70, Sec. 2, Academia Rd., Nankang, Taipei 115, Taiwan (R.O.C.)

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